منابع مشابه
Gene Editing Versus Morphants
Kok et al. conclude that results with Morpholino oligos, which are not recapitulated by natural mutations or gene editing mutations, must be due to off-target effects and, when morphants and mutants differ, they contend that antisense oligo studies should be disregarded. Morpholinos and gene editing mutagenesis are very different technologies and, even if both work perfectly, may yield differen...
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Synthesis of Ebola virus (EBOV) surface glycoprotein (GP) is dependent on transcriptional RNA editing. Northern blot analysis of EBOV-infected cells using GP-gene-specific probes reveals that, in addition to full-length GP messenger RNAs (mRNAs), a shorter RNA is also synthesized, representing >40% of the total amount of GP mRNA. Sequence analysis demonstrates that this RNA is a truncated versi...
متن کاملEthics and germline gene editing.
T he current kerfuffle around the use of CRISPR/Cas9 and other gene editing technologies in human germline research is the latest in a series of related controversies at the intersection of science, medicine, and ethics [1]. Soon after a prominent ad hoc group of scientists called for a moratorium on clinical applications of germline gene editing [2], a research group from China published an ar...
متن کاملSummit on Human Gene Editing
The case for rapid use of gene-editing technology The rise of the platform economy Rethinking society's active orientation Data-driven science policy Super-muscly pigs: Trading ethics for efficiency
متن کاملCore Concept: CRISPR gene editing.
Just a few years ago, molecular biologists hoping to alter the genome of their favorite organisms faced an arduous task and likely weeks of genetic tinkering. Today, those scientists can quickly destroy or edit a gene with a new technology called CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9. “It really opens up the genome of virtually every organism that’s been sequenc...
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ژورنال
عنوان ژورنال: Zebrafish
سال: 2015
ISSN: 1545-8547,1557-8542
DOI: 10.1089/zeb.2015.1114